Nick (Jesse Eisenberg) is a slacking pizza delivery driver who has trouble completing the "30 Minutes or Less" policy that his employers issue, and it causes him to get yelled at by his boss (Brett Gelman). He hangs out with his friend Chet (Aziz Ansari), a substitute teacher. After a nasty argument between the two over Chet finding out that Nick had slept with Chet's sister Katie (Dilshad Vadsaria), whom Nick still has feelings for, and Nick finding out that Chet was the reason Nick's parents divorced after he told Nick's dad that his wife had an affair with a lifeguard, they break off their friendship.
Meanwhile, two delinquents, Dwayne (Danny McBride) and Travis (Nick Swardson) are miserable living under the shadow of Dwayne's domineering father (Fred Ward). Dwayne confides in a stripper, Juici (Bianca Kajlich), about his contempt for his dad, who is squandering the money that he won playing the lottery. Juici says she can hire an assassin to kill Dwayne's dad for $100,000 so Dwayne can collect the inheritance. Dwayne plots that they kidnap a complete stranger and force him to rob a bank for the hit money by strapping a bomb to his chest, which Travis will make, as he is skilled with explosives. After seeing an advertisement for the pizzeria that Nick works at, they order a pizza and wait for the driver to come to their hideout, which is in the middle of a scrapyard. When Nick arrives, the two quickly knock him out.
When Nick wakes up, he finds a vest rigged with explosives strapped and buckled onto his torso. Dwayne and Travis (who are masked) tell him his situation: if he doesn't rob a bank in ten hours, they will detonate the bomb. Failure to comply or going to the police will also result in them detonating the bomb, as they will be monitoring him most of the time. Nick, in his panic, goes to a school where Chet is working and desperately pleads with him to help. After plans to deactivate or remove the bomb are dashed, Chet says he has no choice but to rob the bank. Still uneasy, Nick asks Chet to assist him. Chet reluctantly agrees on the grounds that he never mentions his sister ever again.
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